What role does immunosuppression play in the success of organ transplants?

Immunosuppression plays a crucial role in the success of organ transplants primarily by minimizing the risk of organ rejection by the host's immune system. When an organ from a donor is transplanted into a recipient, the recipient's body may recognize the transplanted organ as foreign due to the differences in histocompatibility antigens. This recognition can trigger an immune response, leading to rejection of the transplanted organ. Administrating immunosuppressive medications helps to dampen or suppress this immune response, allowing the body to accept the donor organ instead of attacking it.

By controlling the immune system's activity, immunosuppression helps facilitate the long-term acceptance of the transplanted organ, making it integral to the overall success of transplantation procedures. It is essential for transplant recipients to adhere to their prescribed immunosuppressive regimen to maintain the function of the transplanted organ and avoid rejection.